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Article

Role of functional polymorphisms of NRAMP1 gene for the development of Crohn's disease.

Inflammatory bowel diseases - 1 Oct 2008

Gazouli Maria, Atsaves Vassilios, Mantzaris Gerassimos, Economou Michalis, Nasioulas George, Evangelou Konstantinos, Archimandritis Athanassios J, Anagnou Nicholas P

Abstract excerpt

BACKGROUND: Crohn's disease (CD) is characterized by chronic activation of macrophages. Natural resistance-associated macrophage protein 1 (NRAMP1) gene exerts many pleiotropic effects on macrophage functions. Hence, NRAMP1 may be also involved in the resistance to intracellular pathogens, and this effector of the innate immunity might be involved in CD pathogenesis. Polymorphic alleles at the NRAMP1 locus have...

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PMID: 18454481
DOI: 10.1002/ibd.20488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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