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Article

The SOS response regulates adaptive mutation.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jun 2000

McKenzie G J, Harris R S, Lee P L, Rosenberg S M

Abstract excerpt

Upon starvation some Escherichia coli cells undergo a transient, genome-wide hypermutation (called adaptive mutation) that is recombination-dependent and appears to be a response to a stressful environment. Adaptive mutation may reflect an inducible mechanism that generates genetic variability in times of stress. Previously, however, the regulatory components and signal transduction pathways controlling adaptive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10829077
DOI: 10.1073/pnas.120161797
PMCID: PMC18688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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