Article
Association mapping in structured populations.
American journal of human genetics - 1 Jul 2000
Pritchard J K, Stephens M, Rosenberg N A, Donnelly P
Abstract excerpt
The use, in association studies, of the forthcoming dense genomewide collection of single-nucleotide polymorphisms (SNPs) has been heralded as a potential breakthrough in the study of the genetic basis of common complex disorders. A serious problem with association mapping is that population structure can lead to spurious associations between a candidate marker and a phenotype. One common solution has been to...
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