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Article

Association analysis of the AIRE and insulin genes in Finnish type 1 diabetic patients.

Immunogenetics - 1 Jun 2006

Turunen Joni A, Wessman Maija, Forsblom Carol, Kilpikari Riika, Parkkonen Maija, Pöntynen Nora, Ilmarinen Tanja, Ulmanen Ismo, Peltonen Leena, Groop Per-Henrik

Abstract excerpt

Mutations in the autoimmune regulator (AIRE) gene cause a recessive Mendelian disorder autoimmune polyendocrinopathy syndrome type 1 (APS-1 or autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy). APS-1 patients develop multiorgan autoimmune diseases including type 1 diabetes (prevalence 12%). The AIRE protein controls the central tolerance induction in the thymus by regulating the expression levels of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16552513
DOI: 10.1007/s00251-006-0088-3

Genes

AIRE
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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