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Article

An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus.

Nature - 23 Aug 2007

Giraud Matthieu, Taubert Richard, Vandiedonck Claire, Ke Xiayi, Lévi-Strauss Matthieu, Pagani Franco, Baralle Francisco E, Eymard Bruno, Tranchant Christine, Gajdos Philippe, Vincent Angela, Willcox Nick, Beeson David, Kyewski Bruno, Garchon Henri-Jean

Abstract excerpt

Promiscuous expression of tissue-restricted auto-antigens in the thymus imposes T-cell tolerance and provides protection from autoimmune diseases. Promiscuous expression of a set of self-antigens occurs in medullary thymic epithelial cells and is partly controlled by the autoimmune regulator (AIR...

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Source

Identifiers

PMID: 17687331
DOI: 10.1038/nature06066

Genes

CHRNA1
AIRE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17687331-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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