Article
Association of polymorphism in the promoter region of the apolipoprotein E gene with diastolic blood pressure in normotensive Japanese.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 May 2000
Katsuya T, Sato N, Asai T, Fukuda M, Takiuchi S, Fu Y, Hanayama R, Moriguchi A, Rakugi H, Higaki J, Ogihara T
Abstract excerpt
The epsilon4 allele of apolipoprotein E (APOE) is reported to be a genetic risk factor of atherosclerosis through hyperlipidemia and late-onset Alzheimer's dementia. A recent report showed that a genetic variant (A -491T) in the promoter region of the APOE gene increases the risk of Alzheimer's disease. In the present study, we examined whether these APOE polymorphisms were genetically involved in essential...
Topics
- Adult
- Aged
- Apolipoproteins E
- Blood Pressure
- Case-Control Studies
- Female
- Genotype
- Humans
- Hypertension
- Japan
- Lipid Metabolism
- Male
- Middle Aged
- Polymorphism, Restriction Fragment Length