Article
Evidence for a prostate cancer-susceptibility locus on chromosome 20.
American journal of human genetics - 1 Jul 2000
Berry R, Schroeder J J, French A J, McDonnell S K, Peterson B J, Cunningham J M, Thibodeau S N, Schaid D J
Abstract excerpt
Recent studies suggest that hereditary prostate cancer is a complex disease involving multiple susceptibility genes and variable phenotypic expression. While conducting a genomewide search on 162 North American families with > or =3 members affected with prostate cancer (PRCA), we found evidence for linkage to chromosome 20q13 with two-point parametric LOD scores >1 at multiple sites, with the highest two-point...
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