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Maintenance of Mest imprinted methylation in blastocyst-stage mouse embryos is less stable than other imprinted loci following superovulation or embryo culture

1 Jul 2017

Abstract excerpt

Assisted reproductive technologies are fertility treatments used by subfertile couples to conceive their biological child. Although generally considered safe, these pregnancies have been linked to genomic imprinting disorders, including Beckwith–Wiedemann and Silver–Russell Syndromes. Silver–Russell Syndrome is a growth disorder characterized by pre- and post-natal growth retardation. The Mest imprinted domain is...

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Share to Epigenetics and DNA Methylation
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PMID: 29492315
DOI: 10.1093/eep/dvx015

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