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Article

Alpha2-macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimer's disease.

Neuroreport - 27 Apr 2000

Higuchi S, Matsushita S, Nakane J, Arai H, Matsui T, Urakami K, Yuzuriha T, Takeda A

Abstract excerpt

Two genetic markers of the plasma protein alpha2-macroglobulin, a 5 bp deletion/insertion at the 5' splice site of exon 18 (A2MI) and the GTC/ATC (VaIIO00IIe) in exon 24 (A2M2), may have roles in the development of Alzheimer's disease (AD). Genotyping and linkage analysis of these markers in 426 Japanese sporadic AD patients, 85 autopsy-confirmed Caucasian AD cases, and, as controls, 382 Japanese and 65...

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PMID: 10817585
DOI: 10.1097/00001756-200004270-00005

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Alpha2-macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimer's disease.PMID 10817585Read ↗

Alpha2-macroglobulin polymorphism is not associated with AD or AD-type neuropathology in the Japanese.Semantic proximity Read ↗

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Alpha-2 macroglobulin is genetically associated with Alzheimer disease.Semantic proximity Read ↗

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Identical distribution of the alpha 2-macroglobulin pentanucleotide deletion in subjects with Alzheimer disease and controls in a German population.Semantic proximity Read ↗

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