Article
Loss of imprinting and allele switching of p73 in renal cell carcinoma.
Oncogene - 1 Oct 1998
Mai M, Qian C, Yokomizo A, Tindall D J, Bostwick D, Polychronakos C, Smith D I, Liu W
Abstract excerpt
p73, a protein that has substantial structural and functional similarity to p53, has recently been identified. It was found to be monoallelically expressed in all cell lines and normal individuals tested. To elucidate its role in cancer development and as a potential imprinted tumor suppressor, we investigated the allele-specific expression of the human p73 gene in 28 cases of renal cell carcinoma and its...
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