Loss of imprinting and allele switching of p73 in renal cell carcinoma.

doi:10.1038/sj.onc.1202099

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Article

Loss of imprinting and allele switching of p73 in renal cell carcinoma.

Oncogene - 1 Oct 1998

Mai M, Qian C, Yokomizo A, Tindall D J, Bostwick D, Polychronakos C, Smith D I, Liu W

Abstract excerpt

p73, a protein that has substantial structural and functional similarity to p53, has recently been identified. It was found to be monoallelically expressed in all cell lines and normal individuals tested. To elucidate its role in cancer development and as a potential imprinted tumor suppressor, w...

Topics

Alleles
Carcinoma, Renal Cell
DNA-Binding Proteins
Female
Genes, Tumor Suppressor
Genomic Imprinting
Humans
Kidney Neoplasms
Male
Nuclear Proteins
Pedigree
Tumor Protein p73
Tumor Suppressor Proteins

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