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Article

Microsatellite instability in patients with multiple primary cancers of the gastrointestinal tract.

Gut - 1 Jun 2000

Yamashita K, Arimura Y, Kurokawa S, Itoh F, Endo T, Hirata K, Imamura A, Kondo M, Sato T, Imai K

Abstract excerpt

BACKGROUND: Little is known about the genetic alterations in multiple primary cancers of the gastrointestinal tract. Microsatellite instability (MSI) is frequently observed in hereditary non-polyposis colorectal cancer (HNPCC), and multiple primary cancers is a feature of this syndrome. AIMS: To identify MSI incidence, target gene mutation, and mismatch repair (MMR) protein status in patients with multiple...

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PMID: 10807889
DOI: 10.1136/gut.46.6.790
PMCID: PMC1756432

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