Article
Microsatellite instability in patients with multiple primary cancers of the gastrointestinal tract.
Gut - 1 Jun 2000
Yamashita K, Arimura Y, Kurokawa S, Itoh F, Endo T, Hirata K, Imamura A, Kondo M, Sato T, Imai K
Abstract excerpt
BACKGROUND: Little is known about the genetic alterations in multiple primary cancers of the gastrointestinal tract. Microsatellite instability (MSI) is frequently observed in hereditary non-polyposis colorectal cancer (HNPCC), and multiple primary cancers is a feature of this syndrome. AIMS: To identify MSI incidence, target gene mutation, and mismatch repair (MMR) protein status in patients with multiple...
Topics
- Aged
- Aged, 80 and over
- Base Pair Mismatch
- Female
- Gastrointestinal Neoplasms
- Humans
- Immunohistochemistry
- Male
- Microsatellite Repeats
- Middle Aged
- Mutation
- Phenotype
- Polymerase Chain Reaction
- Protein Serine-Threonine Kinases