Article
Genetic effects on susceptibility, clinical expression, and treatment outcome of type 1 autoimmune hepatitis.
Clinics in liver disease - 1 Aug 2002
Donaldson Peter T, Czaja Albert J
Abstract excerpt
Currently, three genetic factors have been short-listed as possible modulators of susceptibility and severity in type 1 AIH. They are female sex, HLA DRB alleles encoding lysine at position DR beta 71, and the CTLA4*G allele. The fourth association (i.e., TNFRSF6) remains to be confirmed. There are many other candidates to investigate. Current hypotheses suggest that the autoimmune genotype will include multiple...
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