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Article

Specific recognition of lamivudine-resistant HIV-1 by cytotoxic T lymphocytes.

AIDS (London, England) - 14 Apr 2000

Schmitt M, Harrer E, Goldwich A, Bäuerle M, Graedner I, Kalden J R, Harrer T

Abstract excerpt

OBJECTIVE: The reverse transcriptase (RT) M184V mutation within the HLA-A2-restricted HIV-1 cytotoxic T lymphocyte (CTL) epitope VL9 (VIYQYMDDL; RT 179-187) not only induces drug escape against lamivudine but also abolished recognition by a CTL clone derived from a long-term non-progressor. To test whether the variant VL9 epitope containing the M184V mutation represents a new CTL epitope, we studied recognition...

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Share to Cytotoxicity, Immunologic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Protease Inhibitors

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Source

Identifiers

PMID: 10807188
DOI: 10.1097/00002030-200004140-00004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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