Article
The immune response to the RT181-189 epitope in HIV-1-infected patients is associated with viral sequence polymorphism flanking the epitope.
Journal of clinical immunology - 1 Aug 2011
Pacheco Yovana, Allavena Clotilde, Guilloux Yannick, Mueller-Schmucker Sandra M, Hueckelhoven Angela G, André-Garnier Elisabeth, Cleon François, Ferré Virginie, Rodallec Audrey, Billaud Eric, Harrer Thomas, Raffi François, McIlroy Dorian
Abstract excerpt
Many drug-resistance mutations in HIV-1 reverse transcriptase fall within cytotoxic T lymphocytes (CTL) epitopes, but studies of the response to these epitopes in patients with virological failure are lacking. We therefore compared IFN-γ ELISPOT responses to the YV9 epitope (RT181-189) covering the lamivudine resistance mutation, M184V, in HLA-A2(+) antiretroviral treatment (ART)-naive patients (n = 19), to those...
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