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Article

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

Nature cell biology - 1 Jul 2005

Difilippantonio Simone, Celeste Arkady, Fernandez-Capetillo Oscar, Chen Hua-Tang, Reina San Martin Bernardo, Van Laethem Francois, Yang Yong-Ping, Petukhova Galina V, Eckhaus Michael, Feigenbaum Lionel, Manova Katia, Kruhlak Michael, Camerini-Otero R Daniel, Sharan Shyam, Nussenzweig Michel, Nussenzweig André

Abstract excerpt

Nijmegen breakage syndrome (NBS) is a chromosomal fragility disorder that shares clinical and cellular features with ataxia telangiectasia. Here we demonstrate that Nbs1-null B cells are defective in the activation of ataxia-telangiectasia-mutated (Atm) in response to ionizing radiation, whereas...

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Identifiers

PMID: 15965469
DOI: 10.1038/ncb1270

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15965469-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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