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Article

Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.

Molecular cancer research : MCR - 1 Jul 2003

Lee Joo Hyeon, Xu Bo, Lee Chang-Hun, Ahn Jun-Young, Song Min Sup, Lee Ho, Canman Christine E, Lee Jong-Soo, Kastan Michael B, Lim Dae-Sik

Abstract excerpt

Phosphorylation of NBS1, the product of the gene mutated in Nijmegen breakage syndrome (NBS), by ataxia telangiectasia mutated (ATM), the product of the gene mutated in ataxia telangiectasia, is required for activation of the S phase checkpoint in response to ionizing radiation (IR). However, NBS1 is also thought to play additional roles in the cellular response to DNA damage. To clarify these additional...

Read the complete abstract on PubMed

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Share to Acid Anhydride Hydrolases
Share to Ataxia Telangiectasia Mutated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Checkpoint Kinase 2

Share to DNA Repair Enzymes

Share to MRE11 Homologue Protein

Share to Radiation, Ionizing

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Source

Identifiers

PMID: 12861053

Genes

ATM
MRE11
BRCA1
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.PMID 12861053Read ↗

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Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.Semantic proximity Read ↗

NBS1 Knockdown by Small Interfering RNA Increases Ionizing Radiation Mutagenesis and Telomere Association in Human CellsSemantic proximity Read ↗

ATM-dependent phosphorylation of nibrin in response to radiation exposure.Semantic proximity Read ↗

Dual role of Nbs1 in the ataxia telangiectasia mutated-dependent DNA damage response.Semantic proximity Read ↗

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