Article
Cytochrome c folds through a smooth funnel.
Protein science : a publication of the Protein Society - 1 Mar 2000
Panda M, Benavides-Garcia M G, Pierce M M, Nall B T
Abstract excerpt
A dominant feature of folding of cytochrome c is the presence of nonnative His-heme kinetic traps, which either pre-exist in the unfolded protein or are formed soon after initiation of folding. The kinetically trapped species can constitute the majority of folding species, and their breakdown limits the rate of folding to the native state. A temperature jump (T-jump) relaxation technique has been used to compare...
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