Article
IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 2000
Suzuki Y, Sher A, Yap G, Park D, Neyer L E, Liesenfeld O, Fort M, Kang H, Gufwoli E
Abstract excerpt
The role for IL-10 in the immunopathogenesis of acute toxoplasmosis following peroral infection was examined in both genetically susceptible C57BL/6 and resistant BALB/c mice. C57BL/6-background IL-10-targeted mutant (IL-10-/-) mice all died in 2 wk after infection with 20 cysts of the ME49 strain, whereas only 20% of control mice succumbed. Histological studies revealed necrosis in the small and large intestines...
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