Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD40/CD154 ligation is required for the development of acute ileitis following oral infection with an intracellular pathogen in mice.

Gastroenterology - 1 Mar 2002

Li Wen, Buzoni-Gatel Dominique, Debbabi Hajer, Hu Mark S, Mennechet Franck J D, Durell Brigit G, Noelle Randolph J, Kasper Lloyd H

Abstract excerpt

BACKGROUND & AIMS: Acute inflammatory ileitis occurs in C57BL/6 mice after oral infection with Toxoplasma gondii. We evaluated the role of CD40/CD154 interaction in the development of acute ileitis in this experimental model. METHODS: CD154-/- and anti-CD154 antibody-treated mice as well as chimeric mice, either C57BL/6 or CD40-/- reconstituted with bone marrow from C57BL/6 or CD40-/- mice, were orally infected...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Antibodies, Monoclonal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD40 Antigens

Share to CD40 Ligand

Share to Cytokines

Share to Mice, Knockout

Share to Toxoplasma

Share to Toxoplasmosis

Source

Identifiers

PMID: 11875009
DOI: 10.1053/gast.2002.31888

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD40/CD154 ligation is required for the development of acute ileitis following oral infection with an intracellular pathogen in mice.PMID 11875009Read ↗

The induction of acute ileitis by a single microbial antigen of Toxoplasma gondii.Semantic proximity Read ↗

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection.Semantic proximity Read ↗

IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii.Semantic proximity Read ↗

Antagonistic Interplay between MicroRNA-155 and IL-10 during Lyme Carditis and Arthritis.Semantic proximity Read ↗

Intraepithelial lymphocytes exhibit selective immunity to intestinal pathogensSemantic proximity Read ↗

Osteopontin and iCD8α Cells Promote Intestinal Intraepithelial Lymphocyte HomeostasisSemantic proximity Read ↗

LRBA Deficiency Can Lead to Lethal Colitis That Is Diminished by SHIP1 Agonism.Semantic proximity Read ↗

A Critical Blimp-1-Dependent IL-10 Regulatory Pathway in T Cells Protects From a Lethal Pro-inflammatory Cytokine Storm During Acute Experimental Trypanosoma brucei InfectionSemantic proximity Read ↗

T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavitySemantic proximity Read ↗

An Exaggerated Immune Response in Female BALB/c Mice Controls Initial Toxoplasma gondii Multiplication but Increases Mortality and Morbidity Relative to Male MiceSemantic proximity Read ↗

Immune responses to Toxoplasma gondii in the gut.Semantic proximity Read ↗

Survival analysis and microarray profiling identify Cd40 as a candidate for the Salmonella susceptibility locus, Ity5.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.