Article
gdt1, a new signal transduction component for negative regulation of the growth-differentiation transition in Dictyostelium discoideum.
Molecular biology of the cell - 1 May 2000
Zeng C, Anjard C, Riemann K, Konzok A, Nellen W
Abstract excerpt
Discoidin I expression was used as a marker to screen for mutants affected in the growth-differentiation transition (GDT) of Dictyostelium. By REMI mutagenesis we have isolated mutant 2-9, an overexpressor of discoidin I. It displays normal morphogenesis but shows premature entry into the developmental cycle. The disrupted gene was denominated gdt1. The mutant phenotype was reconstructed by disruptions in...
Topics
- 3' Untranslated Regions
- Amino Acid Sequence
- Animals
- Cell Differentiation
- Cell Division
- Dictyostelium
- Discoidins
- Folic Acid
- Gene Expression Regulation
- Genetic Techniques
- Lectins
- Membrane Proteins
- Molecular Sequence Data
- Mutation