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Article

Aberrations of the B-cell receptor B29 (CD79b) gene in chronic lymphocytic leukemia.

Blood - 15 Aug 1997

Thompson A A, Talley J A, Do H N, Kagan H L, Kunkel L, Berenson J, Cooper M D, Saxon A, Wall R

Abstract excerpt

Leukemic B cells in chronic lymphocytic leukemia (B-CLL) typically exhibit low or undetectable surface Ig. Because the B29 (CD79b and Ig beta) and mb-1 (CD79a and Ig alpha) gene products are required for surface Ig display in the B-cell receptor complex (BCR), we analyzed the expression of these genes in B-CLL cells. The majority (83%) of the randomly selected B-CLL patient samples analyzed exhibited low or...

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Source

Identifiers

PMID: 9269755

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Aberrations of the B-cell receptor B29 (CD79b) gene in chronic lymphocytic leukemia.PMID 9269755Read ↗

Widespread B29 (CD79b) gene defects and loss of expression in chronic lymphocytic leukemia.Semantic proximity Read ↗

Aberrant B cell receptor signaling from B29 (Igbeta, CD79b) gene mutations of chronic lymphocytic leukemia B cells.Semantic proximity Read ↗

The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism.Semantic proximity Read ↗

An Alternatively Spliced Form of CD79b Gene May Account for Altered B-Cell Receptor Expression in B-Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion.Semantic proximity Read ↗

Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).Semantic proximity Read ↗

Defective assembly of the B‐cell receptor chains accounts for its low expression in B‐chronic lymphocytic leukaemiaSemantic proximity Read ↗

The promoter and 5' flanking sequences controlling human B29 gene expressionSemantic proximity Read ↗

Mechanism of CD79A and CD79B Support for IgM+ B Cell Fitness through B Cell Receptor Surface ExpressionSemantic proximity Read ↗

Igbeta(CD79b) mRNA expression in chronic lymphocytic leukaemia cells correlates with immunoglobulin heavy chain gene mutational status but does not serve as an independent predictor of clinical severity.Semantic proximity Read ↗

Identification of a secondary promoter within the human B cell receptor component gene hCD79b.Semantic proximity Read ↗

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