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Article

Widespread B29 (CD79b) gene defects and loss of expression in chronic lymphocytic leukemia.

Leukemia & lymphoma - 1 Feb 1999

Thompson A A, Do H N, Saxon A, Wall R

Abstract excerpt

Chronic Lymphocytic Leukemia (CLL) is the most prevalent form of leukemia in Western countries, and is characterized by a monoclonal proliferation of primarily immature CD5+ B lymphocytes. The molecular biology of chronic leukemias and lymphomas remains largely unresolved. Surface immunoglobulin (Ig) expression, which is often decreased in CLL, requires the protein product of the B29 gene for translocation of the...

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Share to Aged, 80 and over
Share to Antigens, CD
Share to CD79 Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

Identifiers

PMID: 10048429
DOI: 10.3109/10428199909058414

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Widespread B29 (CD79b) gene defects and loss of expression in chronic lymphocytic leukemia.PMID 10048429Read ↗

Aberrations of the B-cell receptor B29 (CD79b) gene in chronic lymphocytic leukemia.Semantic proximity Read ↗

Aberrant B cell receptor signaling from B29 (Igbeta, CD79b) gene mutations of chronic lymphocytic leukemia B cells.Semantic proximity Read ↗

The promoter and 5' flanking sequences controlling human B29 gene expressionSemantic proximity Read ↗

Defective assembly of the B‐cell receptor chains accounts for its low expression in B‐chronic lymphocytic leukaemiaSemantic proximity Read ↗

The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism.Semantic proximity Read ↗

An Alternatively Spliced Form of CD79b Gene May Account for Altered B-Cell Receptor Expression in B-Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion.Semantic proximity Read ↗

Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemiaSemantic proximity Read ↗

Surface antigen expression and correlation with variable heavy-chain gene mutation status in chronic lymphocytic leukemia.Semantic proximity Read ↗

Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).Semantic proximity Read ↗

Minimal region of loss at 13q14 in B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

Igbeta(CD79b) mRNA expression in chronic lymphocytic leukaemia cells correlates with immunoglobulin heavy chain gene mutational status but does not serve as an independent predictor of clinical severity.Semantic proximity Read ↗

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