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Article

Are aberrant transcripts of FHIT, TSG101, and PTEN/MMAC1 oncogenesis related?

International journal of molecular medicine - 1 May 1999

Wang N M, Chang J G

Abstract excerpt

Tumor suppressor gene mutations in TSG101, FHIT, and PTEN/MMAC1 were found in many types of cancer and the defects in these genes are responsible for the tumor development. Since aberrant transcripts of these genes were also identified in normal tissues, the significance of these mutations in carcinogenesis has become a controversy. To determine large deletions or other alterations in these genes, we analyzed the...

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Source

Identifiers

PMID: 10202180
DOI: 10.3892/ijmm.3.5.491

Genes

FHIT
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Are aberrant transcripts of FHIT, TSG101, and PTEN/MMAC1 oncogenesis related?PMID 10202180Read ↗

Clinical implications of aberrant TSG101 transcripts in acute myeloblastic leukemia.Semantic proximity Read ↗

Alternative splicing, but not allelic loss, of the FHIT gene increases with development of lung cancer.Semantic proximity Read ↗

Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tract.Semantic proximity Read ↗

[Relationship between aberrant FHIT transcripts and hepatocellular carcinoma].Semantic proximity Read ↗

Anomalous transcripts and allelic deletions of the FHIT gene in human esophageal cancer.Semantic proximity Read ↗

Abnormalities of the FHIT transcripts in osteosarcoma and Ewing sarcoma.Semantic proximity Read ↗

Aberration of FHIT gene is associated with increased tumor proliferation and decreased apoptosis-clinical evidence in lung and head and neck carcinomas.Semantic proximity Read ↗

p53 induction prevents accumulation of aberrant transcripts in cancer cells.Semantic proximity Read ↗

Multiple truncated transcripts of TSG101 in gastrointestinal cancers.Semantic proximity Read ↗

Expression of aberrant functional and nonfunctional transcripts of the FHIT gene in Burkitt's lymphomas.Semantic proximity Read ↗

Aberrant splicing but not mutations of TSG101 in human breast cancer.Semantic proximity Read ↗

Role of TSG101 in uterine cervix cancer.Semantic proximity Read ↗

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