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Article

Human SP-A protein variants derived from one or both genes stimulate TNF-alpha production in the THP-1 cell line.

American journal of physiology. Lung cellular and molecular physiology - 1 May 2000

Wang G, Phelps D S, Umstead T M, Floros J

Abstract excerpt

In humans, two functional genes of surfactant protein (SP) A, SP-A1 and SP-A2, and several alleles of each functional gene have been characterized. SP-A is a multimeric molecule consisting of six trimers. Each trimer contains two SP-A1 molecules and one SP-A2 molecule. Until now, it has been unclear whether a single SP-A gene product is functional or whether there are functional differences either among alleles...

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Identifiers

PMID: 10781424
DOI: 10.1152/ajplung.2000.278.5.L946

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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