Imprinted Long Non-Coding RNAs in Mammalian Development and Disease.

Abstract excerpt

Imprinted genes play diverse roles in mammalian development, homeostasis, and disease. Most imprinted chromosomal domains express one or more long non-coding RNAs (lncRNAs). Several of these lncRNAs are strictly nuclear and their mono-allelic expression controls in cis the expression of protein-coding genes, often developmentally regulated. Some imprinted lncRNAs act in trans as well, controlling target gene...

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• Share to Alleles
• Share to Embryo, Mammalian
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