Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence.

Blood - 1 Aug 2006

Datta Abhik, Bellon Marcia, Sinha-Datta Uma, Bazarbachi Ali, Lepelletier Yves, Canioni Danielle, Waldmann Thomas A, Hermine Olivier, Nicot Christophe

Abstract excerpt

The antiviral thymidine analog azidothymidine (AZT) is used to treat several virus-associated human cancers. However, to date the mechanism of AZT action remains unclear and thus, reasons for treatment failure are unknown. Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy of poor prognosis. Here, we report that enduring AZT treatment of T-cell leukemia virus I-infected cells, in vitro and in vivo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Senescence
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to Human T-lymphotropic virus 1

Share to Leukemia-Lymphoma, Adult T-Cell

Share to Telomerase

Share to Tumor Suppressor Protein p14ARF

Share to Zidovudine

Source

Open in PubMed Open full text

Identifiers

PMID: 16569765
DOI: 10.1182/blood-2006-01-0067
PMCID: PMC1895862

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence.PMID 16569765Read ↗

AZT as a telomerase inhibitorSemantic proximity Read ↗

Replication Stress Tolerance in Adult T-Cell LeukemiaSemantic proximity Read ↗

The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathwaySemantic proximity Read ↗

5-aza-2′-deoxycytidine-mediated c-myc Down-regulation Triggers Telomere-dependent Senescence by Regulating Human Telomerase Reverse Transcriptase in Chronic Myeloid LeukemiaSemantic proximity Read ↗

Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A.Semantic proximity Read ↗

Effects of Reverse Transcriptase Inhibitors on Telomere Length and Telomerase Activity in Two Immortalized Human Cell LinesSemantic proximity Read ↗

Role of tumor suppressor genes in the development of adult T cell leukemia/lymphoma (ATLL).Semantic proximity Read ↗

p53-dependent down-regulation of telomerase is mediated by p21waf1.Semantic proximity Read ↗

Telomerase inhibition enhances apoptosis in human acute leukemia cells: possibility of antitelomerase therapy.Semantic proximity Read ↗

The Epstein-Barr virus replication and transcription activator, Rta/BRLF1, induces cellular senescence in epithelial cellsSemantic proximity Read ↗

The suppressed proliferation and premature senescence by ganciclovir in p53-mutated human non-small-lung cancer cells acquiring herpes simplex virus-thymidine kinase cDNA.Semantic proximity Read ↗

Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.