Article
Retrovirus vector-mediated stable gene silencing in human cell.
Biochemical and biophysical research communications - 16 Jan 2004
Liu Chang-Mei, Liu De-Pei, Dong Wen-Ji, Liang Chih-Chuan
Abstract excerpt
RNA interference (RNAi) is the mechanism of sequence-specific, post-transcriptional gene silencing initiated by short interfering RNAs (siRNAs) homologous to the gene being suppressed. siRNAs, which mediate sequence-specific mRNA degradation, are duplexes of about 21-23 nucleotides with 3'-overha...
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