Molecular defects in colorectal tumorigenesis.

Abstract excerpt

Colorectal cancers, whether sporadic or hereditary, are caused by a defined set of molecular events affecting genes that control proliferation, differentiation and senescence of intestinal cells. There are at least two different pathogenetic pathways for colorectal cancer: the chromosomal instability pathway and the microsatellite instability pathway. These different pathways, however, converge on common...

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