Article
Malignancies in Down syndrome.
Indian journal of pediatrics - 1 Jan 2000
Kusumakumary P, Vats T S, Ankathil R, Gattamaneni H R, Nair M K
Abstract excerpt
Down Syndrome (DS) is associated with an increased incidence of malignancies, especially leukaemias. We came across 8 DS children presenting with malignancies and having trisomy 21 as the sole cytogenetic abnormality. Of these 8 DS cases, 4 presented with acute lymphocytic leukaemia, 2 with acute myeloid leukaemia and one case each with Hodgkin's disease and Wilms' tumour. There are contradictory reports...
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