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Article

Tumor necrosis factor-alpha-238 and -308 polymorphisms do not associated with traits related to obesity and insulin resistance.

Diabetes - 1 Oct 1999

Walston J, Seibert M, Yen C J, Cheskin L J, Andersen R E

Abstract excerpt

Tumor necrosis factor-alpha (TNF-alpha) is expressed primarily in adipocytes, and elevated levels of this cytokine have been linked to obesity and insulin resistance. The purpose of this investigation was to test whether the TNF-alpha-308 polymorphism (previously linked to insulin resistance and increased leptin levels) and the TNF-alpha-238 polymorphism (linked to decreased insulin resistance) were associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10512379
DOI: 10.2337/diabetes.48.10.2096

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Tumor necrosis factor-alpha-238 and -308 polymorphisms do not associated with traits related to obesity and insulin resistance.PMID 10512379Read ↗

Association between TNF-α promoter G-308A and G-238A polymorphisms and obesity.Semantic proximity Read ↗

Tumor necrosis factor alpha -238 and -308 polymorphisms do not associate with insulin resistance in hypertensive subjects.Semantic proximity Read ↗

Influence of two polymorphisms of the tumoral necrosis factor-alpha gene on the obesity phenotype.Semantic proximity Read ↗

The -238 and -308 G-->A polymorphisms of the tumor necrosis factor alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians.Semantic proximity Read ↗

Tumor necrosis factor-alpha--308 G/A polymorphism in obese Caucasians.Semantic proximity Read ↗

TNF-αG-308A polymorphism is associated with insulin resistance: a meta-analysis.Semantic proximity Read ↗

The tumour necrosis factor alpha -238 G --> A and -308 G --> A promoter polymorphisms are not associated with insulin sensitivity and insulin secretion in young healthy relatives of Type II diabetic patients.Semantic proximity Read ↗

Association of the TNF-alpha -308 G/A promoter polymorphism with insulin resistance in obesity.Semantic proximity Read ↗

The G-308A variant of the Tumor Necrosis Factor-α (TNF-α) gene is not associated with obesity, insulin resistance and body fat distributionSemantic proximity Read ↗

Tumor necrosis factor alpha gene G-308A polymorphism, insulin resistance, and fasting plasma glucose in young, older, and diabetic Japanese men.Semantic proximity Read ↗

The association of TNF-α -308G/A and -238G/A polymorphisms with type 2 diabetes mellitus: a meta-analysis.Semantic proximity Read ↗

Meta-analysis on the G-308A tumor necrosis factor alpha gene variant and phenotypes associated with the metabolic syndrome.Semantic proximity Read ↗

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