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Article

Tumor necrosis factor alpha -238 and -308 polymorphisms do not associate with insulin resistance in hypertensive subjects.

Metabolism: clinical and experimental - 1 Dec 2001

Sheu W H, Lee W J, Lin L Y, Chang R L, Chen Y T

Abstract excerpt

It is well established that, as a group, patients with essential hypertension are characterized by insulin resistance. Previous studies have shown that a biallelic polymorphism in the tumor necrosis factor (TNF)alpha promoter position -308 and -238 might be involved in the insulin resistance state in diabetic and/or nondiabetic subjects. We determined these polymorphisms in 235 nondiabetic hypertensive subjects...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11735091
DOI: 10.1053/meta.2001.27192

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Tumor necrosis factor alpha -238 and -308 polymorphisms do not associate with insulin resistance in hypertensive subjects.PMID 11735091Read ↗

The tumour necrosis factor alpha -238 G --> A and -308 G --> A promoter polymorphisms are not associated with insulin sensitivity and insulin secretion in young healthy relatives of Type II diabetic patients.Semantic proximity Read ↗

Tumor necrosis factor-alpha-238 and -308 polymorphisms do not associated with traits related to obesity and insulin resistance.Semantic proximity Read ↗

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Tumor necrosis factor alpha gene G-308A polymorphism in the metabolic syndrome.Semantic proximity Read ↗

The -238 and -308 G-->A polymorphisms of the tumor necrosis factor alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians.Semantic proximity Read ↗

Tumor necrosis factor alpha gene G-308A polymorphism, insulin resistance, and fasting plasma glucose in young, older, and diabetic Japanese men.Semantic proximity Read ↗

Lack of association between the -308 polymorphism of the tumor necrosis factor-alpha gene and the insulin resistance syndrome.Semantic proximity Read ↗

TNF-αG-308A polymorphism is associated with insulin resistance: a meta-analysis.Semantic proximity Read ↗

Meta-analysis on the G-308A tumor necrosis factor alpha gene variant and phenotypes associated with the metabolic syndrome.Semantic proximity Read ↗

Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM).Semantic proximity Read ↗

Association between TNF-α promoter G-308A and G-238A polymorphisms and obesity.Semantic proximity Read ↗

Tumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease.Semantic proximity Read ↗

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