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Article

The basic helix-loop-helix transcription factor E47 reprograms human pancreatic cancer cells to a quiescent acinar state with reduced tumorigenic potential.

Pancreas - 1 Jul 2015

Kim SangWun, Lahmy Reyhaneh, Riha Chelsea, Yang Challeng, Jakubison Brad L, van Niekerk Jaco, Staub Claudio, Wu Yifan, Gates Keith, Dong Duc Si, Konieczny Stephen F, Itkin-Ansari Pamela

Abstract excerpt

OBJECTIVES: Pancreatic ductal adenocarcinoma (PDA) initiates from quiescent acinar cells that attain a Kras mutation, lose signaling from basic helix-loop-helix (bHLH) transcription factors, undergo acinar-ductal metaplasia, and rapidly acquire increased growth potential. We queried whether PDA cells can be reprogrammed to revert to their original quiescent acinar cell state by shifting key transcription...

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Identifiers

PMID: 25894862
DOI: 10.1097/MPA.0000000000000328
PMCID: PMC4464938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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