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Article

Glucocorticoid receptor gene mutations in leukemic cells acquired in vitro and in vivo.

Cancer research - 1 Apr 2000

Hillmann A G, Ramdas J, Multanen K, Norman M R, Harmon J M

Abstract excerpt

Glucocorticoid resistance was investigated in human leukemic CCRF-CEM cells. A mutation (L753F), which renders the human glucocorticoid receptor (hGR) gene functionally hemizygous, was identified in all CEM-derived cell lines analyzed. Allele-specific PCR identified the same mutation in lymph node biopsy material from patient CEM cells. Given the correlation between hGR concentration and glucocorticoid...

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Share to Deoxyribonucleases, Type II Site-Specific
Share to Leukemia
Share to Lymph Nodes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Point Mutation

Share to Polymorphism, Single-Stranded Conformational

Share to Receptors, Glucocorticoid

Share to T-Lymphocytes

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 10766198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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