Article
A new look at the microtubule binding patterns of dimeric kinesins.
Journal of molecular biology - 14 Apr 2000
Hoenger A, Thormählen M, Diaz-Avalos R, Doerhoefer M, Goldie K N, Müller J, Mandelkow E
Abstract excerpt
The interactions of monomeric and dimeric kinesin and ncd constructs with microtubules have been investigated using cryo-electron microscopy (cryo-EM) and several biochemical methods. There is a good consensus on the structure of dimeric ncd when bound to a tubulin dimer showing one head attached directly to tubulin, and the second head tethered to the first. However, the 3D maps of dimeric kinesin motor domains...
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