Single-molecule microtubule dynamics measurements reveal an intermediate state and clarify the role of nucleotide.

Abstract excerpt

Microtubules are polymers of αβ-tubulin heterodimers that undergo GTPase dependent polymerization dynamics to organize the intracellular space and mediate faithful chromosome segregation. Microtubule dynamics derive from biochemical properties of individual tubulin subunits and how they interact with the polymer end, a complex environment where individual tubulins can have different numbers of neighbor contacts....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Binding Sites
• Share to Guanosine Diphosphate