Article
p53 mutations in hairy cell leukemia.
Leukemia - 1 Apr 2000
König E A, Kusser W C, Day C, Porzsolt F, Glickman B W, Messer G, Schmid M, de Châtel R, Marcsek Z L, Demeter J
Abstract excerpt
We have studied the frequency of p53 mutations in genomic DNA extracted from peripheral blood or the spleen of 61 patients with hairy cell leukemia using PCR-SSCP and automated cycle sequencing. We identified exon 5-8 mutations in 17 cases, corresponding to a frequency of 28%. In four cases, mutations were localized in exon 5; one patient with atypical HCL had a mutation in exon 6 at the 3' boundary; five cases...
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