Article
Recurrent CDKN1B (p27) mutations in hairy cell leukemia.
Blood - 20 Aug 2015
Dietrich Sascha, Hüllein Jennifer, Lee Stanley Chun-Wei, Hutter Barbara, Gonzalez David, Jayne Sandrine, Dyer Martin J S, Oleś Małgorzata, Else Monica, Liu Xiyang, Słabicki Mikołaj, Wu Bian, Troussard Xavier, Dürig Jan, Andrulis Mindaugas, Dearden Claire, von Kalle Christof, Granzow Martin, Jauch Anna, Fröhling Stefan, Huber Wolfgang, Meggendorfer Manja, Haferlach Torsten, Ho Anthony D, Richter Daniela, Brors Benedikt, Glimm Hanno, Matutes Estella, Abdel Wahab Omar, Zenz Thorsten
Abstract excerpt
Hairy cell leukemia (HCL) is marked by near 100% mutational frequency of BRAFV600E mutations. Recurrent cooperating genetic events that may contribute to HCL pathogenesis or affect the clinical course of HCL are currently not described. Therefore, we performed whole exome sequencing to explore the mutational landscape of purine analog refractory HCL. In addition to the disease-defining BRAFV600E mutations, we...
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