Article
Patched 2, located in 1p32-34, is not mutated in high stage neuroblastoma tumors.
International journal of oncology - 1 May 2000
Jögi A, Abel F, Sjöberg R M, Toftgård R, Zaphiropoulos P G, Påhlman S, Martinsson T, Axelson H
Abstract excerpt
Neuroblastoma is a childhood malignancy originating from cells of the sympathetic nervous system, exhibiting a marked diversity in outcome, with spontaneous regression at one end of the spectrum and severe disease and death at the other end. Features associated with frequent recurrence, a poor prognosis, and high tumor stage are loss of heterozygosity in the distal region of chromosome 1p and amplification of the...
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