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Article

Characterization of an acyclovir-resistant herpes simplex virus type 2 strain isolated from a premature neonate.

The Journal of infectious diseases - 1 Apr 2000

Oram R J, Marcellino D, Strauss D, Gustafson E, Talarico C L, Root A K, Sharma P L, Thompson K, Fingeroth J D, Crumpacker C, Herold B C

Abstract excerpt

Acyclovir resistance is not a recognized problem among neonates with perinatal herpes simplex virus (HSV) infection. A premature newborn with neurocutaneous HSV infection was treated for 21 days with acyclovir. Disseminated disease recurred 8 days later. A recurrent isolate was resistant to acyclovir and lacked thymidine kinase activity on the basis of a frameshift mutation in the thymidine kinase (tk) gene....

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Identifiers

PMID: 10762577
DOI: 10.1086/315387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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