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Article

Mutagenic Analysis of the C-Terminal Extension of Lsm1.

PloS one - 1 Jan 2016

Chowdhury Ashis, Kalurupalle Swathi, Tharun Sundaresan

Abstract excerpt

The Sm-like proteins (also known as Lsm proteins) are ubiquitous in nature and exist as hexa or heptameric RNA binding complexes. They are characterized by the presence of the Sm-domain. The Lsm1 through Lsm7 proteins are highly conserved in eukaryotes and they form a hetero-octameric complex together with the protein Pat1. The Lsm1-7-Pat1 complex plays a key role in mRNA decapping and 3'-end protection and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27434131
DOI: 10.1371/journal.pone.0158876
PMCID: PMC4951014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Mutagenic Analysis of the C-Terminal Extension of Lsm1.PMID 27434131Read ↗

lsm1 mutations impairing the ability of the Lsm1p-7p-Pat1p complex to preferentially bind to oligoadenylated RNA affect mRNA decay in vivo.Semantic proximity Read ↗

Mutations in the Saccharomyces cerevisiae LSM1 gene that affect mRNA decapping and 3' end protection.Semantic proximity Read ↗

Activation of decapping involves binding of the mRNA and facilitation of the post-binding steps by the Lsm1-7-Pat1 complex.Semantic proximity Read ↗

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The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa.Semantic proximity Read ↗

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