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Article

Impaired up-regulation of CD86 in B cells of "type A" common variable immunodeficiency patients.

European journal of immunology - 1 Apr 2000

Denz A, Eibel H, Illges H, Kienzle G, Schlesier M, Peter H H

Abstract excerpt

Common variable immunodeficiency (CVID) is characterized by defective B cell maturation and antibody formation resulting in low serum antibody levels of most or all Ig isotypes. A specific subgroup of patients ("type A") has normal numbers of mature surface (s)IgM / sIgD- positive circulating B cells. However, since these lymphocytes do not respond to in vitro stimulation by differentiation and Ig synthesis, they...

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Source

Identifiers

PMID: 10760795
DOI: 10.1002/(SICI)1521-4141(200004)30:4<1069::AID-IMMU1069>3.0.CO;2-M

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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