Article
Impaired up-regulation of CD86 in B cells of "type A" common variable immunodeficiency patients.
European journal of immunology - 1 Apr 2000
Denz A, Eibel H, Illges H, Kienzle G, Schlesier M, Peter H H
Abstract excerpt
Common variable immunodeficiency (CVID) is characterized by defective B cell maturation and antibody formation resulting in low serum antibody levels of most or all Ig isotypes. A specific subgroup of patients ("type A") has normal numbers of mature surface (s)IgM / sIgD- positive circulating B cells. However, since these lymphocytes do not respond to in vitro stimulation by differentiation and Ig synthesis, they...
Topics
- Adult
- Aged
- Antigens, CD
- B-Lymphocytes
- B7-2 Antigen
- CD40 Antigens
- Cells, Cultured
- Child
- Common Variable Immunodeficiency
- Down-Regulation
- Female
- Flow Cytometry
- Humans
- Lymphocyte Activation
- Male