Article
B cell lines from a subset of patients with common variable immunodeficiency undergo enhanced apoptosis associated with an increased display of CD95 (Apo-1/fas), diminished CD38 expression, and decreased IgG and IgA production.
Cellular immunology - 1 Nov 1995
Guo B C, Saxon A
Abstract excerpt
Investigation of common variable immunodeficiency (CVI) is hampered by lack of a suitable in vitro models. We have developed EBV-transformed B lymphoblastoid cell lines from a selected subset of CVI patients and characterized them for phenotypic and functional properties that provide evidence for...
Topics
- ADP-ribosyl Cyclase
- ADP-ribosyl Cyclase 1
- Antigens, CD
- Antigens, Differentiation
- Apoptosis
- B-Lymphocytes
- Cell Death
- Cell Line, Transformed
- Common Variable Immunodeficiency
- Humans
- Immunoglobulin A
- Immunoglobulin G
- Membrane Glycoproteins
- N-Glycosyl Hydrolases
- Phenotype
- Receptors, Antigen, B-Cell
- fas Receptor