Dissection of the Pre-Germinal Center B-Cell Maturation Pathway in Common Variable Immunodeficiency Based on Standardized Flow Cytometric EuroFlow Tools.

doi:10.3389/fimmu.2020.603972

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Article

Dissection of the Pre-Germinal Center B-Cell Maturation Pathway in Common Variable Immunodeficiency Based on Standardized Flow Cytometric EuroFlow Tools.

Frontiers in immunology - 1 Jan 2020

Del Pino-Molina Lucía, López-Granados Eduardo, Lecrevisse Quentin, Torres Canizales Juan, Pérez-Andrés Martín, Blanco Elena, Wentink Marjolein, Bonroy Carolien, Nechvatalova Jana, Milota Tomas, Kienzler Anne-Kathrin, Philippé Jan, Sousa Ana E, van der Burg Mirjam, Kalina Tomas, van Dongen Jacques J M, Orfao Alberto

Abstract excerpt

Introduction: Common Variable Immunodeficiency (CVID) is characterized by defective antibody production and hypogammaglobulinemia. Flow cytometry immunophenotyping of blood lymphocytes has become of great relevance for the diagnosis and classification of CVID, due to an impaired differentiation of mature post-germinal-center (GC) class-switched memory B-cells (MBC) and severely decreased plasmablast/plasma cell...

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PMID: 33679693
DOI: 10.3389/fimmu.2020.603972
PMCID: PMC7925888

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