Article
Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model.
Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2000
Fang J, Shing Y, Wiederschain D, Yan L, Butterfield C, Jackson G, Harper J, Tamvakopoulos G, Moses M A
Abstract excerpt
Among the earliest and most important stages during tumorigenesis is the activation of the angiogenic process, an event that is termed the "switch to the angiogenic phenotype." We have developed an in vivo system that can reliably recapitulate the stages in tumor development that represent this transition. Using this model, we have harvested and studied tumor nodules that can be distinguished from each other on...
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