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Article

The Striatum Is Highly Susceptible to Mitochondrial Oxidative Phosphorylation Dysfunctions

6 Jul 2011

Abstract excerpt

Neuronal oxidative phosphorylation (OXPHOS) deficiency has been associated with a variety of neurodegenerative diseases, including Parkinson's disease and Huntington's disease. However, it is not clear how mitochondrial dysfunction alone can lead to a preferential elimination of certain neuronal populations in vivo. We compared different types of neuronal populations undergoing the same OXPHOS deficiency to...

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PMID: 21734281
DOI: 10.1523/jneurosci.6223-10.2011

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