Article
Isolation of low molecular mass polypeptide complementary DNA clones from primitive vertebrates. Implications for the origin of MHC class I-restricted antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1996
Kandil E, Namikawa C, Nonaka M, Greenberg A S, Flajnik M F, Ishibashi T, Kasahara M
Abstract excerpt
Proteasomes are the multisubunit proteases thought to be involved in the generation of peptides presented by MHC class I molecules. When cells are stimulated with IFN-gamma, two MHC encoded subunits, LMP2 and LMP7, are incorporated into the proteasomal complex, presumably by displacing the housek...
Topics
- Amino Acid Sequence
- Animals
- Antigen Presentation
- Base Sequence
- Cysteine Endopeptidases
- DNA Primers
- DNA, Complementary
- Endopeptidases
- Fishes
- Genetic Variation
- Hagfishes
- Histocompatibility Antigens Class I
- Humans
- Lampreys