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Article

Mutations induced by some DNA minor groove binding alkylators in AS52 Chinese hamster cells.

Mutation research - 14 Mar 2000

Wu X C, Marcinkowski K, Turner P M, Ferguson L R

Abstract excerpt

Nitrogen mustards are commonly used in cancer chemotherapy. They interact with DNA at electronegative sites, primarily forming N7 guanine mono-adducts and interstrand cross-links. Targeting nitrogen mustards to DNA by attachment of a DNA minor groove binding carrier such as the bisbenzimidazoles Hoechst 33258 (pibenzimol) or Hoechst 33342 (HOE) makes it possible to direct DNA alkylation to more specific stretches...

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Identifiers

PMID: 10751621
DOI: 10.1016/s0027-5107(99)00229-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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