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Article

A lethal perinatal cardiac phenotype resulting from altered integrin function in cardiomyocytes.

Journal of cardiac failure - 1 Aug 2002

Valencik Maria L, Keller Rebecca S, Loftus Joseph C, McDonald John A

Abstract excerpt

BACKGROUND: Integrins are heterodimeric receptors that couple the extracellular matrix to intracellular signaling pathways and the cyoskeleton. Integrins are strain transducers and candidates for modulators or effectors of cardiac hypertrophy. METHODS: To begin to probe this function, we have transgenically expressed a chimeric protein that alters integrin function in cardiomyocytes. The transgene (Tac-beta(1D))...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12397575
DOI: 10.1054/jcaf.2002.127335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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