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Article

ATM protein synthesis patterns in sporadic breast cancer.

Molecular pathology : MP - 1 Oct 1999

Kairouz R, Clarke R A, Marr P J, Watters D, Lavin M F, Kearsley J H, Lee C S

Abstract excerpt

AIMS: The gene mutated in ataxia-telangiectasia (A-T), designated ATM (for "A-T mutated"), is believed to be associated with an increased risk of developing breast cancer. Most patients with A-T have null mutations of the ATM gene that appear to give rise to a truncated nonfunctional ATM protein. Therefore, the increased risk of breast cancer reported in A-T heterozygotes appears to be the result of...

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Source

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Identifiers

PMID: 10748873
DOI: 10.1136/mp.52.5.252
PMCID: PMC395706

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATM protein synthesis patterns in sporadic breast cancer.PMID 10748873Read ↗

Lack of defective expression of the ATM gene in sporadic breast cancer tissues and cell lines.Semantic proximity Read ↗

Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history.Semantic proximity Read ↗

Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer.Semantic proximity Read ↗

ATM-heterozygous germline mutations contribute to breast cancer-susceptibility.Semantic proximity Read ↗

Ataxia-telangiectasia: phenotype/genotype studies of ATM protein expression, mutations, and radiosensitivity.Semantic proximity Read ↗

Cancer risk in ATM heterozygotes: a model of phenotypic and mechanistic differences between missense and truncating mutations.Semantic proximity Read ↗

Dominant negative ATM mutations in breast cancer families.Semantic proximity Read ↗

Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer.Semantic proximity Read ↗

The ATM gene and breast cancer: is it really a risk factor?Semantic proximity Read ↗

Ataxia-telangiectasia: identification and detection of founder-effect mutations in the ATM gene in ethnic populations.Semantic proximity Read ↗

ATM mutations in sporadic lymphoid tumours.Semantic proximity Read ↗

No evidence for constitutional ATM mutation in breast/gastric cancer families.Semantic proximity Read ↗

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