Article
No evidence for constitutional ATM mutation in breast/gastric cancer families.
International journal of oncology - 1 Jun 1998
Bay J O, Grancho M, Pernin D, Presneau N, Rio P, Tchirkov A, Uhrhammer N, Verrelle P, Gatti R A, Bignon Y J
Abstract excerpt
Ataxia-Telangiectasia (A-T) is a rare autosomal recessive disease characterised by cutaneous telangiectasia, cerebellar ataxia, immunodeficiency, high sensitivity to ionising radiation, chromosomal instability and an increased risk of cancer. The gene mutated in A-T patients, ATM, is located on c...
Topics
- Adult
- Aged
- Ataxia Telangiectasia
- Binding Sites
- Breast Neoplasms
- DNA Mutational Analysis
- DNA, Complementary
- Exons
- Family
- Family Health
- Fathers
- Female